| Studies in humans and animals generally indicate that toluene does not cause cancer. The EPA has determined that the carcinogenicity of toluene can not be classified. Skin contact may result in mild irritation initially. Prolonged contact is more irritating due to the defatting action of this solvent and dermatitis (dry, red skin) may result. Liquid toluene is absorbed through the skin slowly. Therefore, other toxic effects would not be expected by this route of exposure. Despite widespread use of toluene, there are no reports of skin sensitization. Basically, compared to a lot of the other solvents found in the lab, as well as regular gasoline, it's pretty benign stuff.
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